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Research Groups

CELLULAR NEUROCIENCE | NEURONAL SIGNALING | CARDIOVASCULAR RESEARCH | METABOLISM | LIPID SIGNALING AND HOMEOSTASIS | ENDOCRINOLOGY | CELLULAR PHYSIOLOGY | TARGETED GENE-EXPRESSION ANALYSIS | MEMBRANE BIOLOGY | TELOMERE RESEARCH

 

CARDIOVASCULAR RESEARCH

Ilkka Tikkanen, M.D., Dr.Med.Sci., Docent
Contact: +358 2 941 25702, E-mail: ilkka.tikkanen@helsinki.fi

The group studies mechanisms of end-organ damage and repair in cardiovascular and renal diseases, notably local expression and regulation of vasoactive factors and apoptosis in hypertension, heart failure, and progression of renal damage. In addition, properties of new cardiovascular drugs are being evaluated. READ MORE

CELLULAR NEUROSCIENCE

Pirta Hotulainen, Ph.D., Docent
Contact: +358 2 941 25710, E-mail: pirta.hotulainen@helsinki.fi

The research in the group focuses on the regulation of the actin cytoskeleton in neurons, and particularly its disturbances in neuropsychiatric diseases. READ MORE

CELLULAR PHYSIOLOGY

Kid Törnqvist, Ph.D., Professor
Contact: +358 2 941 25706, E-mail: kid.tornqvist@abo.fi

The main topic of the research is to understand the physiological significance of sphingolipid derivatives as regulators of calcium and potassium channels, and sphgingolipids as regulators of thyroid cancer cell function. READ MORE

ENDOCRINOLOGY

Hannele Yki-Järvinen, M.D., Dr.Med.Sci., F.R.C.P, Professor
Contact: +358 2941 25709, E-mail: yki-jarvinen@helsinki.fi

The main goal is to study the causes and consequences of insulin resistance in humans with a special focus on the role of fat accumulation in the liver. READ MORE

LIPID SIGNALING AND HOMEOSTASIS

Vesa Olkkonen, Ph.D., Professor
Contact: +358 2 941 25705, E-mail: vesa.olkkonen@helsinki.fi

The research group investigates new regulatory mechanisms that our cells employ to maintain their lipid balance and to integrate their lipid status with other vital functions such as vesicle transport and cell signaling. The work aims at the identification of novel mechanisms that impact the development of cardiovascular diseases and fatty liver/metabolic syndrome, the long-term aim being to find new approaches for the prevention and treatment of these diseases. READ MORE

MEMBRANE BIOLOGY

Elina Ikonen, M.D., Dr.Med.Sci., Professor
Contact: +358 2941 25277, E-mail: elina.ikonen@helsinki.fi

We aim to learn how cholesterol and related sterols move in the intracellular milieu and the sterol compartmentalization in cells is maintained. We also want understand how changes in cellular cholesterol homeostasis lead to human diseases, and what can be done to improve their detection and treatment.The main targets of our study are the molecular machineries of intracellular cholesterol transport and the mechanisms controlling distribution of cholesterol and related sterols in distinct membrane domains. We approach these questions by employing a variety of molecular cell biological, in vitro biochemical/physical, and advanced imaging approaches. READ MORE

METABOLISM

Heikki Koistinen, M.D., Dr.Med.Sci., Docent
Contact: +358 2 941 25710, E-mail: heikki.koistinen@helsinki.fi

The main interest of the group is to understand the molecular mechanisms regulating insulin sensitivity in skeletal muscle. We are particularly interested in how lipid excess contributes to skeletal muscle insulin resistance, and how lipid-induced insulin resistance can be reversed.
READ MORE

NEURONAL SIGNALING

Dan Lindholm, M.D. Dr.Med.Sci., Professor
Contact: +358 2 941 25400, E-mail: dan.lindholm@helsinki.fi

We study basic mechanisms underlying neurodegenerative diseases with focus on cell death pathways and proteins with the aim to contribute to better therapies to combat cell degeneration. We further study synaptic degeneration and protein ubiquitination and neurotrophic factor signaling in neurons as well as neural stem cells and their differentiation and responses. READ MORE

TARGETED GENE-EXPRESSION ANALYSIS

Jakob Stenman, M.D, Dr.Med.Sci., Docent
E-mail: jakob.stenman@helsinki.fi

The aim of the study group is to develop new multigene predictor assays for cancer diagnostics with the main focus on colon, prostate and breast cancer. In these disease groups there are approximately 500.000 new cases yearly in Europe and the US. Diagnostic gene sets for smaller disease groups such as Barrett's esophagus and primary Sclerosing Cholangitis in which there are specific difficulties with currently available diagnostic tests are also being developed. READ MORE

TELOMERE RESEARCH

Frej Fyhrquist, M.D., Dr.Med.Sci., Dhc, Professor emeritus
Contact: +358 2941 25710, E-mail: frej.fyhrquist@helsinki.fi

The group has focused on vasoactive peptides, their functions and receptors. More recently, telomeres in cardiovascular disease has become our new field of interest. bREAD MORE


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